All

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 C10 Nervous System Diseases D009422 +
  C10.597 Neurologic Manifestations D009461 +
   C10.597.606 Neurobehavioral Manifestations D019954 +
    C10.597.606.643 Mental Retardation D008607 +
     C10.597.606.643.220 Down Syndrome D004314 
 C16 Congenital, Hereditary, and Neonatal Diseases and Abnormalities D009358 +
  C16.131 Abnormalities D000013 +
   C16.131.077 Abnormalities, Multiple D000015 +
    C16.131.077.327 Down Syndrome D004314 
 C16 Congenital, Hereditary, and Neonatal Diseases and Abnormalities D009358 +
  C16.131 Abnormalities D000013 +
   C16.131.260 Chromosome Disorders D025063 +
    C16.131.260.260 Down Syndrome D004314 
 C16 Congenital, Hereditary, and Neonatal Diseases and Abnormalities D009358 +
  C16.320 Genetic Diseases, Inborn D030342 +
   C16.320.180 Chromosome Disorders D025063 +
    C16.320.180.260 Down Syndrome D004314